پیشروی واکنشهای متوالی الی از طریق کاتالیزورهای مایعات یونی و مستقربربستر جامد

abstract in first part of this project, the use of a new and biguanid-like catalyst supported on silica as a recyclable catalyst provides a new route for the synthesis of a variety of arylalkylidene rhodanine derivatives through knoevenagle reaction in at present of solvent at room temperature. rhodanine derivatives and especially arylalkylidene rhodanines have proven to be attractive compounds due to their outstanding biological activities and have undergone rapid development as anticonvulsant, antibacterial, and antidiabetic agents. in continue, for the synthesis of 4, 4-(arylmethylene)-bis-(1h-pyrazol-5-ols) and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones, using of a new and inexpensive ionic liquid provides in the cascade reaction in the absence of solvent at room temperature. 2-, 4-dihydro-3h-pyrazol-3-one derivatives are an important class of bio-active drug targets in the pharmaceutical industry, as they are the core structure of numerous biologically active compounds. this new ionic liquid has been used as an efficient catalyst for the first time and causes a remarkable decrease in the reaction time. therefore, we believe that the work reported here would have the potential application in green chemistry. finally, we described for the first time a mild, efficient and green process was developed for synthesis new compounds of (6-hydroxy-5-((5-hydroxy-1-phenyl-3-methyl-5-pyrazolo-4-yl)(arylmethyl)-1,3-dimethyl barbituric utilizing relatively novel and cost effective synthesized acidic ionic liquid. isolation of the product was simple and did not require solvent work-up. we described the application of cascade reactions for products synthesis under mild condition.